实体瘤中低氧普遍存在,而骨肉瘤作为骨骼组织中实体瘤的一种具体表现形式,其肿瘤组织内亦应存在低氧状态。低氧诱导因子1是组织细胞在低氧条件下一系列基因转录和级联反应的重要调控因子。在实体瘤中,低氧诱导因子1可通过调控肿瘤细胞血管生成、凋亡、能量代谢、pH值、反转录端粒酶活性及侵袭和转移,从而抑制肿瘤细胞生长和调控肿瘤细胞适应性反应。 Hypoxia is common in solid tumors, while osteosarcoma, as a specific manifestation of solid tumors in bone tissue, should also have hypoxia in the tumor tissue. Hypoxia-inducible factor-1 is an important regulator of a series of gene transcription and cascade reactions of tissue cells under hypoxic conditions. In solid tumors, hypoxia inducible factor 1 can inhibit tumor cell growth and regulate tumor cell adaptability by regulating tumor cell angiogenesis, apoptosis, energy metabolism, pH, telomerase activity and invasion and metastasis reaction.