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核纤层蛋白(Lamins)属中等纤维蛋白家族(IF),其多聚体组成网格状结构紧贴于内层核膜内表面,在维持核的正常形态以及在核周期性的解体和重组装过程中发挥重要作用。蛋白内部不同位点的缺失和突变目前已知可引起四种不同的临床综合征。
Lamins belong to the intermediate fibrin family (IF), the multi-member network of which is in close contact with the inner surface of the inner nuclear membrane. In maintaining the normal morphology of the nucleus and in the nuclear disintegration and recombination Play an important role in the process. Deletions and mutations at different sites within the protein are now known to cause four different clinical syndromes.