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目的研究血同型半胱氨酸(Hcy)水平与脑梗死及原发性高血压病的关系。方法收集脑梗死合并高血压病患者60例(A组),原发性高血压病患者30例(B组),正常对照30例(C组),测定血生化指标,对脑梗死患者行NIH评分。结果 (1)A组、B组及C组血Hcy浓度分别为(27.16±10.46)μmol/L、(20.11±3.17)μmol/L、(13.35±1.82)μmol/L,两两比较差异有统计学意义(P<0.05)。(2)血Hcy浓度与血糖、甘油三酯、低密度脂蛋白、血压的相关性分析表明,血Hcy水平与各指标间无相关性。(3)A组中高Hcy组的NIH评分为(5.77±3.66)分,明显高于非高Hcy组的(2.70±1.06)分(P<0.01),而血压水平无统计学差异。结论高Hcy血症是脑梗死的独立危险因素,临床对于合并高血压等传统危险因素的脑梗死患者应积极筛查高Hcy血症。
Objective To study the relationship between plasma homocysteine (Hcy) levels and cerebral infarction and essential hypertension. Methods Sixty patients with cerebral infarction complicated with hypertension (group A), 30 patients with essential hypertension (group B) and 30 normal controls (group C) were enrolled in this study. Blood biochemical parameters were measured and NIH score. Results (1) The concentrations of Hcy in group A, B and C were (27.16 ± 10.46) μmol / L, (20.11 ± 3.17) μmol / L and (13.35 ± 1.82) μmol / L respectively Significance (P <0.05). (2) The correlation between blood Hcy concentration and blood glucose, triglyceride, low density lipoprotein, blood pressure showed that the blood Hcy level had no correlation with each index. (3) The NIH score of middle and high Hcy group was (5.77 ± 3.66) points in group A, which was significantly higher than that of non-high Hcy group (2.70 ± 1.06) (P <0.01), but there was no significant difference in blood pressure level. Conclusion Hyperhomocysteinemia is an independent risk factor of cerebral infarction. Clinically, hyperhomocysteinemia should be actively screened in cerebral infarction patients with traditional risk factors such as hypertension.