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目的：研究人视网膜星形胶质细胞的发育及与血管前体细胞的关系。材料和方法：收集１３４例发育各期胎儿视网膜和４例成人视网膜，石蜡包埋切片和整装铺片，四种抗体免疫组化染色，光镜观察。结果：星形胶质细胞分为三种：①Ｓ－１００（＋）／胶质纤维酸性蛋白（ＧＦＡＰ）（＋）的双极形星形胶质细胞，于１３周经视盘进入视网膜，与跟随其后的纤连蛋白（Ｆｎ）（＋）的血管前体细胞接触并相伴向锯齿缘迁移。足月后和成人此类星形胶质细胞主要位于节细胞层，突起包裹节细胞层和神经纤维层中的血管及神经纤维束。②Ｓ－１００（－）／ＧＦＡＰ（＋）双极形星形胶质细胞和③星状星形胶质细胞。后两类细胞晚于血管前体细胞进入视网膜，与后者无伴行关系。足月后和成人，细胞体分布于节细胞层，突起包裹节细胞层和内核层内、外缘的血管。结论：人视网膜内存在形态学和免疫学特点不同的三种星形胶质细胞。其中 Ｓ－１００（＋）／ＧＦＡＰ（＋）的星形胶质细胞可能参与了血管发生。
Objective: To study the development of human retinal astrocytes and its relationship with vascular precursor cells. MATERIAL AND METHODS: 134 cases of developing retina and 4 adult retinas, paraffin-embedded sections and monoliths were collected. Immunohistochemistry and immunohistochemistry were used to observe the four kinds of antibodies. RESULTS: Astrocytes were divided into three groups: ① Bipolar astrocytes of S100 (+) / glial fibrillary acidic protein (GFAP) (+) entered the retina at 13 weeks via optic disc, Subsequent fibronectin (Fn) (+) precursor cells contact and migrate toward the serrated edge. After full-term and adult such astrocytes are mainly located in the ganglion cell layer, protruding parietal ganglion cells and nerve fiber layer in the vascular and nerve fiber bundles. ② S-100 (-) / GFAP (+) bipolar astrocytes and ③ astrocytes. The latter two types of cells later than the precursor cells into the retina, with no relationship between the latter. After full-term and adult, the cell body is distributed in the cell layer of the cell layer, and the blood vessels in the inner and outer edges of the parietal cell layer and the inner parietal cell nucleus are raised. Conclusion: There are three types of astrocytes in human retina with different morphological and immunological characteristics. Among them, astrocytes with S-100 (+) / GFAP (+) may be involved in angiogenesis.