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目的 探讨白细胞介素 10 (IL 10 )、白细胞介素 12 (IL 12 )与吉兰 巴雷综合征 (GBS)的关系。方法 用免疫酶联双抗体夹心 (ELISA)法对 3 6例急性期、恢复期GBS患者血清及脑脊液 (CSF)中IL 10、IL 12进行检测。结果 GBS急性期患者血清IL 10水平较对照组未见显著变化 (P >0 0 5 ) ,恢复期则明显升高 (P <0 0 1) ;GBS急性期患者血清IL 12水平较对照组明显升高 (P <0 0 1) ,且其水平与病情分级正相关 ,恢复期明显下降 ;恢复期血清IL 10与IL 12存在负直线相关关系 ;GBS急性期、恢复期CSF中IL 10、IL 12的水平与血清中类似。结论 IL 10、IL 12与GBS的致病过程明显相关 ,IL 10通过下调免疫起保护作用 ,它可能使脱失髓鞘修复 ;IL 12上调免疫参与致病 ,它可能促使脱髓鞘和轴索变性 ;GBS患者血 神经、脑屏障受到一定程度破坏
Objective To investigate the relationship between interleukin 10 (IL 10), interleukin 12 (IL 12) and Guillain-Barre syndrome (GBS). Methods IL 10 and IL 12 in serum and cerebrospinal fluid (CSF) of 36 patients with acute and convalescent GBS were detected by enzyme-linked immunosorbent assay (ELISA). Results Serum levels of IL-10 in acute stage of GBS were significantly lower than those in control group (P <0.05), and were significantly increased in recovery stage (P <0.01). Serum level of IL-12 in patients with acute GBS stage was significantly higher than that in control group (P <0.01), and its level was positively correlated with the grading of disease, and the recovery period was significantly decreased. There was a negative linear correlation between serum IL-10 and IL-12 in recovery phase. IL 10, IL The level of 12 is similar to that in serum. Conclusions IL 10 and IL 12 are significantly associated with the pathogenesis of GBS. IL 10 may play a protective role through down-regulation of immunity, which may dementia remodeling. IL 12 up-regulation is involved in pathogenesis, which may promote demyelination and axonal Degeneration; GBS patients blood nerves, brain barrier to some extent damaged