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目的：探讨ＮＯ与肝胆淤积的关系。方法：以ＡＮＩＴ诱发大鼠肝胆淤积，动态观察内源性ＮＯ、血清常规胆淤指标和肝组织线粒体功能及其相互关系。结果：ＡＮＩＴ大鼠急性期血清胆红素、ＡＬＴ、ＡＫＰ和胆酸明显升高，伴随血和肝组织ＮＯ升高和肝线粒体ＳＤＨ下降。缓解期血胆红素、肝组织ＮＯ升高和肝线粒体ＳＤＨ活性下降仍持续。恢复期，上述改变均趋于正常。结论：肝组织ＮＯ增加可能通过改变肝线粒体能量代谢而影响胆汁分泌过程，而血清ＮＯ升高可能有利于消除血液中增加的异常物质。
Objective: To explore the relationship between NO and hepatobiliary deposition. METHODS: Hepatic cholestasis was induced by ANIT in rats. Endogenous NO, serum routine cholestatic index and mitochondrial function of liver were observed dynamically. Results: Serum bilirubin, ALT, AKP and bile acid were significantly increased in acute stage of ANIT rats, accompanied by increased NO in blood and liver tissue and decreased SDH in liver mitochondria. During remission, serum bilirubin, NO in liver tissue and the decrease of SDH activity in liver mitochondria still persisted. Recovery period, the above changes are normal. CONCLUSION: Increased NO in liver tissue may affect the process of bile secretion by changing the energy metabolism of liver mitochondria. However, elevated serum NO may be beneficial to eliminate the abnormal substances added in the blood.