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1986年12月29日,启东肝癌研究所的肝癌遗传因素群体分析及大鼠癌变过程和阻断实验研究两个课题在江苏省启东县通过鉴定。 1.原发性肝癌在各高发区具有明显的家族聚集性,为探索遗传易感性在启东肝癌高发现场中的地位,以阐明其在肝癌病因中的作用,从1983年开始,调查了1,065例肝癌先证者的家系,从群体水平论证了肝癌家族聚集性,证实了肝癌家系成员是一组高危险人群,其相对危险性为自然人群的5～7倍。运用遗传流行病学调查方法所进行的分离比和遗传度的估计,
On December 29th, 1986, Qidong Hepatocarcinal Institute’s population analysis of liver cancer genetic factors and rat carcinogenesis process and blocking experimental research were identified in Qidong County, Jiangsu Province. 1. Primary hepatocellular carcinoma (HCC) has obvious family clustering in high incidence areas. To explore the role of genetic susceptibility in the high-risk field of liver cancer in Qidong in order to elucidate its role in liver cancer etiology. From 1983, 1,065 cases were investigated. The families of hepatocellular carcinoma probands demonstrated the family clustering of liver cancer from the group level, and confirmed that the family members of the liver cancer family are a group of high-risk groups. The relative risk is 5 to 7 times that of the natural population. Estimates of segregation ratios and heritability using genetic epidemiological survey methods,