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A two-stage liver resection is a surgical option in patients with bilobar liver tumors in whom a single procedure is not feasible because of insufficient functional volume of the future liver remnant. The use of unilateral portal vein occlusion, such as portal vein embolization, induce hypertrophy of the future liver remnant in order to enable subsequent resection. Concomitant enhancement of tumor growth along with the hypertrophy response has raised conces regarding oncological outcomes of the procedure.