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妊高征的病因仍不清楚。作者的研究结果认为在妊高征病程中,由于血管内皮细胞的PGI_2合成酶活性降低引起PGI_2减少和由于血小板的TXA_2合成酶活性亢进引起的TXA_2增加,而出现在PGI_2/TXA_2比率上TXA_2占优势的情况,对妊高征的病态形成起着重要作用。 为了选择性地抑制TXA_2合成,使PGI_2在PGI_2/TXA_2中占优势,以改善妊高征的病情。试用TXA_2合成酶抑制剂ozagrel并探讨其疗效。治疗对象是按日本妇产科学会的妊高征分类,诊断为重症,用降压剂治疗无效的早期发病的重度妊高征4例病人。年龄平均34岁,初、经产各2例。3例主征为高血压,1例主征为蛋白尿。妊高征的平均发病时期为孕31周5日。 给药方法以sodium ozagrel160rag为1日量,溶于5％葡萄糖注射液500ml中持续24小时静脉滴
The cause of PIH remains unclear. The authors concluded that TXA2 predominates in the PGI2 / TXA2 ratio due to decreased PGI2 activity due to reduced PGI2 synthase activity in vascular endothelial cells and increased TXA2 due to platelet TXA2 synthase activity over the course of PIH Of the situation, the pathogenesis of pregnancy-induced hypertension plays an important role. To selectively inhibit TXA_2 synthesis, PGI_2 predominates in PGI_2 / TXA_2 to ameliorate PIH. Try TXA2 synthase inhibitor ozagrel and explore its efficacy. The treatment object is according to the Japan Institute of Obstetrics and Gynecology pregnancy-induced hypertension classification, diagnosis of severe, with antihypertensive agents ineffective early onset of severe pregnancy-induced hypertension in 4 patients. The average age of 34 years, early and late production in 2 cases. 3 cases of the main sign of hypertension, 1 main levy of proteinuria. The average incidence of PIH is 31 weeks of pregnancy on the 5th. Method of administration To sodium ozagrel160rag on the 1st, dissolved in 500ml of 5% glucose injection for 24 hours intravenous infusion