肿瘤干细胞(cancer stem cell,CSC)模型提出:肿瘤是由一小群肿瘤干细胞演化而来的,并与不同分化程度的细胞共同构成肿瘤,其中肿瘤干细胞具有自我更新能力,并且在表观遗传影响下分化形成不同的非致瘤性细胞,最终形成肿瘤[1-4]。因此,鉴定并描述这些为数极少的肿瘤干细胞对于治疗此类肿瘤非常关键。 The cancer stem cell (CSC) model suggests that tumors are evolved from a small group of tumor stem cells and form tumors together with cells of different differentiation degrees. Among them, tumor stem cells have self-renewal ability and are affected by epigenetic influences Differentiation to form different non-tumorigenic cells, the final formation of tumors [1-4]. Therefore, identifying and describing these very few cancer stem cells is critical for the treatment of such tumors.