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1994年美国有关人士估计诊断为恶性黑色素瘤的有3万多例,死亡约7000人,恶性黑色素瘤发病率呈上升的趋势,目前对于这种转移性疾病缺少治疗方法和新的有效制剂。由于 IL-1α和消炎痛在体内抗肿瘤效果有协同性,该文作者在患有黑色素瘤病人中进行了Ⅱ期疗效观察,使用Ⅰ期试验确定的有抗肿瘤活性的剂量。从1990～1992年对49例病人进行了研究,将
In 1994, relevant US personnel estimated that there were more than 30,000 cases of malignant melanoma and about 7,000 deaths. The incidence of malignant melanoma has been on the rise. Currently, there is a lack of treatment methods and new effective preparations for this type of metastatic disease. Since IL-1α and indomethacin have synergistic anti-tumor effects in vivo, the authors performed a phase II efficacy observation in patients with melanoma and used a phase I trial to determine the dose with anti-tumor activity. From 49 to 49 patients were studied from 1990 to 1992.