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目的:探讨糖尿病视网膜病变(DR)患者多次住院(住院次数≥2)的影响因素。方法:以2型糖尿病(DM)并因糖尿病视网膜病变(DR)相关并发症多次住院(住院次数≥2)的患者为实验组,对照组为非糖尿病多次因眼科相关疾病住院(住院次数≥2)患者。比较两组患者在第二次住院时的发病年龄、空腹血糖(fasting blood glucose,GLU)、糖化血清蛋白(glycated serum protrin,GSP)、丙氨酸氨基转移酶(Alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、肌酐(creatinine,Cr)、尿素(urea)、总胆汁酸(total bile acid,TBA)、血清尿酸(uric acid,UA)、甘油三酯(triglycetide,TG)、胆固醇(cholesterol,Ch)、体质指数(body mass index,BMI)等。结果:单因素分析结果显示入院时血糖、糖化血清蛋白、血清尿酸、甘油三酯、胆固醇与DR患者多次住院(住院次数≥2)显著相关(P均≤0.01)。多因素Logistic回归分析显示:空腹血糖(P=0.038;95%CI:1.101~26.325)、糖化血清蛋白(P=0.003;95%CI:1.017~1.082)、尿酸(P=0.167;95%CI:0.994~1.032)、甘油三脂(P=0.023;95%CI:1.774~2228.179)、胆固醇(P=0.029;95%CI:1.317~166.317)水平是DR患者多次住院(住院次数≥2)的独立危险因素。结论:空腹血糖、糖化血清蛋白、尿酸、甘油三脂和胆固醇是DR患者多次住院(住院次数≥2)的独立危险因素。
Objective: To investigate the influential factors of multiple hospitalizations (hospitalization ≥ 2) in patients with diabetic retinopathy (DR). Methods: Patients in type 2 diabetes mellitus (DM) with multiple hospitalizations due to diabetic retinopathy (≥ 2 hospitalizations) were included in the study. Patients in the control group were hospitalized for ophthalmology-related diseases on multiple occasions ≥2) patients. The onset age, fasting blood glucose (GLU), glycated serum protein (GSP), alanine aminotransferase (ALT), aspartate Aspartate aminotransferase (AST), creatinine (Cr), urea, total bile acid (TBA), uric acid (UA), triglycetide TG, cholesterol, body mass index (BMI) and so on. Results: The results of univariate analysis showed that there was a significant correlation between blood glucose, glycosylated serum protein, serum uric acid, triglyceride and cholesterol in multiple hospitalizations (hospitalization ≥ 2) on admission (P ≤ 0.01). Multivariate logistic regression analysis showed that fasting blood glucose (P = 0.038; 95% CI: 1.101-26.325), glycosylated serum protein (P = 0.003; 95% CI: 1.017-1.0882), uric acid 0.994 ~ 1.032), triglyceride (P = 0.023; 95% CI: 1.774-2228.179) and cholesterol (P = 0.029; 95% CI: 1.317-166.317) Independent risk factors. Conclusion: Fasting plasma glucose, glycosylated serum protein, uric acid, triglyceride and cholesterol are independent risk factors for multiple hospitalizations (hospitalization ≥ 2) in DR patients.