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目的 为了评价左氧氟沙星对慢性阻塞性肺病下呼吸道感染的治疗作用。方法 将 6 2例慢性阻塞性肺病下呼吸道感染患者 ,随机分为两组。治疗组 35例 ,采用左氧氟沙星 0 .2 g口服 ,每日 2次 ;对照组 2 7例 ,采用头孢克罗0 .2 5 g口服 ,每日 3次 ,两组疗程均为 7天。结果 左氧氟沙星治疗组的总有效率为 88.6 % ,细菌清除率为 85 .7% ;头孢克罗治疗组的总有效率为 85 .2 % ,细菌清除率为 86 .7%。两组相比差异无显著性 (P>0 .90 )。两组患者共分离出病原菌43株 ,对左氧氟沙星敏感者占 83.7% ,对头孢克罗敏感者占 88.4%。治疗过程中不良反应 ,两组患者均较轻微。结论 左氧氟沙星治疗慢性阻塞性肺病下呼吸道感染具有较好的治疗价值
Objective To evaluate the therapeutic effect of levofloxacin on respiratory tract infections in patients with chronic obstructive pulmonary disease. Methods Sixty-two patients with chronic obstructive pulmonary disease with lower respiratory tract infection were randomly divided into two groups. The treatment group of 35 cases, the use of levofloxacin 0. 2 g orally, 2 times a day; control group of 27 cases, the use of cefaclor 0. 25 g orally, 3 times a day, the two courses were 7 days. Results The total effective rate of levofloxacin group was 88.6% and the bacterial clearance rate was 85.7%. The total effective rate of cefaclor group was 85.2% and the bacterial clearance rate was 86.7%. There was no significant difference between the two groups (P> 0.90). 43 strains of pathogens were isolated from both groups, 83.7% were sensitive to levofloxacin, 88.4% were sensitive to cefaclor. Adverse reactions in the course of treatment, two groups of patients were minor. Conclusion Levofloxacin has good therapeutic value in the treatment of lower respiratory tract infection in chronic obstructive pulmonary disease