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本文报道用反复冷冻-解冻方法制备的消炎痛聚乙烯醇(PVA)凝胶,冷冻-解冻的次数对凝胶强度及释药的影响,并试用戊二醛溶液使凝胶交联作药物的控释试验。结果表明,PVA聚合度影响冷冻凝胶的物理强度。PVA聚合度(500、1000、1700、2400)越大,凝胶的强度亦越大,针入度值则越小。针入度并随冷冻-解冻次数的增加而减小,3～4次以上时,针入度值几乎不变。聚合度>1000的PVA作为释药基质已具有足够的物理强度。PVA浓度对凝胶强度也有影响,聚合度1000的PVA浓度>5%时,随反复次数增加而针入度减小,凝胶强度增加,
This article reports the effect of the amount of indomethacin polyvinyl alcohol (PVA) gel prepared by repeated freezing-thawing methods on the gel strength and drug release by freezing-thawing and uses a glutaraldehyde solution to crosslink the gel as a drug Controlled release test. The results show that the degree of polymerization of PVA affects the physical strength of frozen gel. The greater the polymerization degree of PVA (500,1000,1700,2400), the greater the gel strength, the smaller the penetration value. Penetration and with the freeze-thaw times increase decreases, 3 to 4 times or more, the penetration value is almost unchanged. PVA with a degree of polymerization of> 1000 has sufficient physical strength as a drug delivery base. The PVA concentration also has an effect on the gel strength. When the PVA concentration of 1000 is higher than 5%, the penetration decreases with the increase of the number of repetitions, and the gel strength increases.