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目的:讨论卡介苗保护儿童结核性脑膜炎(结脑)的效果,探讨儿童现行卡介苗(BCG)免疫策略。方法:严格采用病例对照研究方法,对入选结脑病例和对照进行调查,以Epi Info流行病学软件建立数据库,进行相应分析,据此测算疫苗效力(VE)。结果:入选42例病例及126例对照。接种BCG(χ2=25.487 3,P=0.000 0)与儿童结脑发病有统计学关联,BCG的VE=89.42%,95%可信区间(CI)为(69%,97%)。结论:接种BCG是儿童结脑保护因素,保护率89.24%。建议继续推行卡介苗免疫策略,以保护儿童免受结脑等重症结核的侵袭。
Objective: To discuss the effect of BCG in protecting children with tuberculous meningitis (tuberculous meningitis) and explore the current immunization strategy of BCG in children. Methods: Strictly using the case-control study method, the selected cases of tuberculosis and control were investigated. The database was established with Epi Info epidemiology software, and the corresponding analysis was conducted to evaluate the vaccine efficacy (VE). Results: 42 cases and 126 controls were enrolled. The incidence of BCG was 89.42% in BCG and 69% (97%) in 95% confidence interval (CI). Conclusion: BCG vaccination is a protective factor for children with cerebral tuberculosis, the protection rate of 89.24%. It is recommended to continue the BCG immunization strategy to protect children from tuberculosis and other severe tuberculosis.