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[目的]总结重组白细胞介素II(rIL-2)治疗单纯疱疹性角膜炎(HSK)的疗效及预防复发的作用。[方法]将确诊的HSK患者随机分为2组,治疗组32例在应用无环鸟苷滴眼液同时联合rIL-2局部及全身应用;对照组30例单纯应用无环鸟苷治疗。治愈后均随访1~2年。[结果]联合用药治疗组的病程较对照组明显缩短(P﹤0.01)。随访结果显示,治疗组的复发率较对照组明显降低(P﹤0.05)。[结论]临床应用rIL-2联合抗病毒药物治疗HSK疗效明显,可缩短病程、降低复发率。
[Objective] To summarize the therapeutic effect of rIL-2 on the treatment of herpes simplex keratitis (HSK) and its effect in preventing recurrence. [Methods] The diagnosed patients with HSK were randomly divided into two groups. The treatment group (32 cases) was treated with acyclovir combined with rIL-2 locally and systemically. The control group (n = 30) was treated with acyclovir alone. All cases were followed up for 1 to 2 years after the cure. [Results] The duration of the combination therapy group was significantly shorter than that of the control group (P <0.01). The follow-up results showed that the recurrence rate of the treatment group was significantly lower than that of the control group (P <0.05). [Conclusion] The clinical application of rIL-2 combined with antiviral drugs in the treatment of HSK has obvious curative effect, which can shorten the course of disease and reduce the recurrence rate.