5-羟色胺(5-HT)是强烈的血管收缩剂,并增强去甲肾上腺素、血管紧张素Ⅱ的效应,可能参与高血压的发病。5-HT 受体按放射配体法可区分为5～HT_1和5-HT_2两种性质不同的受体。现知5-HT 的药理和生理学作用与5-HT_2受体有关。作者用一种新的选择性5-HT_2受体拮抗剂 Ke-tanserin 对12例原发性高血压患者进行研究,了解该药对高血压的血液动力学影响。其中男性8例,女性4例,年龄59±4(40～77)岁,均确诊为原发性高血压。试验前停药3周,接受含定量钠、钾的膳食。 Serotonin (5-HT) is a strong vasoconstrictor and enhances the effect of norepinephrine and angiotensin II, which may be involved in the pathogenesis of hypertension. 5-HT receptors by radioligand method can be divided into 5 ~ HT_1 and 5-HT_2 two different properties of the receptor. It is known 5-HT pharmacological and physiological role and 5-HT 2 receptor. The authors used a new selective 5-HT 2 receptor antagonist Ke-tanserin study of 12 patients with essential hypertension to understand the drug on the hemodynamic effects of hypertension. There were 8 males and 4 females, aged 59 ± 4 (40-77 years), all of whom were diagnosed as essential hypertension. Before stopping the test for 3 weeks, with a dose of sodium, potassium meal.