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目的 探讨宫颈分泌物细胞因子 (IL - 1β和IL - 6 )含量与细菌性阴道病 (BV)、早产的关系。 方法 选择孕 32～ 34周无宫缩而胎膜完整的有BV孕妇 2 7例和无BV孕妇 30例 ,以及胎膜完整的未足月临产孕妇 2 5例和足月临产孕妇 2 6例 ,进行宫颈分泌物取样 ,分别采用酶联免疫吸附法和放射免疫法测定宫颈分泌物IL -1β、IL - 6的含量。 结果 宫颈分泌物IL - 1β的含量在BV组和未足月临产组均高于无BV组 (P <0 0 5 ) ,而未足月临产组与足月临产组间无差异 (P >0 0 5 ) ;宫颈分泌物IL - 6的含量各组相比均无显著性差异 (P >0 0 5 )。结论 宫颈分泌物IL - 1β含量的升高与BV及早产有关 ,可能在BV引起的早产中起一定的作用
Objective To investigate the relationship between the contents of cytokines (IL - 1β and IL - 6) in cervical secretions and bacterial vaginosis (BV) and premature delivery. Methods Twenty-three to 34-week pregnant women without contractions and intact membranes were included in the study. Twenty-seven BV women and 30 women without BV were enrolled in this study. Twenty-five pregnant women with incomplete fetal membranes and 26 pregnant women with full- Samples of cervical secretions were taken and the contents of IL - 1β and IL - 6 in cervical secretions were determined by enzyme - linked immunosorbent assay and radioimmunoassay respectively. Results The content of IL - 1β in cervical secretions was significantly higher in BV group than in non - BV group (P <0.05), while no difference between non - full - term labor group and full - term labor group (P> 0) There was no significant difference in the content of IL - 6 in cervical secretions between groups (P> 0.05). Conclusion The increase of IL - 1β in cervical secretions is related to BV and premature delivery, which may play a role in the premature delivery of BV