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目的:探讨肝病患者血清甲胎蛋白(AFP)、癌胚抗原(CEA)、血清铁蛋白(SF)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(GGT)、糖类抗原125(CA125)、糖类抗原153(CA153)、糖类抗原199(CA199)及AFP与CEA、CA125、CA153、CA199联合检测在各类肝脏疾病中的临床意义。方法:80例健康体检者为对照组,1000例肝病患者为肝脏疾病组,采用电化学发光分析仪检测AFP、CEA、SF、CA125、CA153、CA199;日立7180全自动生化分析仪检测ALP、GGT,并进行统计学分析。结果:肝癌组369例(36.90%),良性肝病组631例(63.10%),肝癌组AFP、CEA、SF、ALP、GGT、CA125、CA153、CA199与对照组及良性肝病组比较;良性肝病组各项指标与对照组比较,差异均有统计学意义(P<0.05或P<0.01);AFP单独检测特异性为92.09%高于其他检测特异性;多项指标联合检测诊断敏感性最高达98.97%与其他指标敏感性比较,差异均有统计学意义(P<0.05)。结论:AFP联合多项肿瘤标志物可提高对各类肝病的鉴别诊断的准确性,减少漏诊率,具有重要临床意义。
Objective: To investigate the clinical significance of serum AFP, CEA, SF, ALP, GGT, carbohydrate antigens 125 (CA125), carbohydrate antigen 153 (CA153), carbohydrate antigen 199 (CA199) and AFP with CEA, CA125, CA153 and CA199 in various liver diseases. Methods: Eighty healthy subjects were selected as the control group. One hundred and thousand patients with liver disease were liver disease group. AFP, CEA, SF, CA125, CA153 and CA199 were detected by electrochemiluminescence analyzer. Hitachi 7180 automatic biochemical analyzer was used to detect ALP, GGT , And statistical analysis. Results: There were 369 cases (36.90%) in liver cancer group and 631 cases (63.10%) in benign liver disease group. AFP, CEA, SF, ALP, GGT, CA125, CA153 and CA199 in hepatocellular carcinoma group were higher than those in control group and benign liver disease group The indexes were significantly different from those of the control group (P <0.05 or P <0.01). The specificity of AFP alone was 92.09% higher than that of the other tests. The sensitivity of multiple detection tests was 98.97 % And other indicators of sensitivity, the differences were statistically significant (P <0.05). Conclusion: AFP combined with a number of tumor markers can improve the accuracy of various types of liver disease differential diagnosis, reduce the rate of misdiagnosis, has important clinical significance.