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作者用豚鼠做实验,探讨为治疗梅尼埃病施行内淋巴囊减压术的同时,把氨基糖甙类药物施用于内淋巴囊,观察其对内耳感受器的影响,以及药物从内淋巴囊向前庭和耳蜗的扩散机制。33只豚鼠,在全麻无菌条件下,经硬膜外颅后凹进路到达内淋巴囊。第一组把10μl庆大霉素(40mg/ml)放在8只豚鼠的内淋巴囊壁表面。第2组将10μl庆大霉素注入8只豚鼠的内淋巴囊内。第三组在17只豚鼠的前庭导水管裂隙周围做一小孔,把4～5粒链霉素粉球放人内淋巴囊腔内,总药量16～20μg,然后修复术创。一月后,无痛处死动物,取出颞骨做切片染色,在光镜下观察,结果发现,第一组对内耳感受器损害不明显,仅4只豚鼠(其中
The authors used guinea pig experiments to explore the treatment of Meniere’s disease endolymphatic sac decompression surgery at the same time, the aminoglycoside drugs applied to the endolymphatic sac to observe its effect on the inner ear receptors, and drugs from the endolymphatic sac to Vestibular and cochlear diffusion mechanism. Thirty-three guinea pigs under sterile conditions of general anesthesia reached the endolymphatic sac via the epidural cranio-concave approach. In the first group, 10 μl of gentamicin (40 mg / ml) was placed on the surface of the endolymphatic wall in 8 guinea pigs. Group 2 Ten microliters of gentamycin was injected into the endolymphatic sac of eight guinea pigs. In the third group, a small hole was made around the fissure of the vestibular aqueduct of 17 guinea pigs. Four to five streptomycin powder balls were placed in the endolymphatic sac cavity with a total dose of 16-20 μg, and then the operation was repaired. One month later, the animals were euthanized and painlessly removed. The temporal bone was sectioned and stained under a light microscope. The results showed that the first group had no significant damage to the inner ear receptors, with only four guinea pigs