体外实验和临床试验表明,各种肿瘤细胞对不同干扰素(IFN)抗增殖作用的敏感性不同。为克服肿瘤细胞对单一种类IFN的不敏感性,有人报道联合应用自然αIFN(IFN-α)和γIFN(IFN-γ),获得较好的协同抗增殖作用。作者用人膀胱癌细胞系RT4和人肺癌细胞系A2182作为检测细胞,在比较各种重组IFN-α(IFN-α_2,比活性为1.7×10 In vitro experiments and clinical trials have shown that different tumor cells have different sensitivities to the antiproliferative effects of different interferons (IFNs). In order to overcome the insensitivity of tumor cells to a single type of IFN, it has been reported that a combination of natural αIFN (IFN-α) and γIFN (IFN-γ) is used to obtain a better synergistic antiproliferative effect. The authors used human bladder cancer cell line RT4 and human lung cancer cell line A2182 as test cells and compared various recombinant IFN-α (IFN-α_2, specific activity of 1.7×10).