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目的:观察那络酮和多巴酚丁胺联合治疗对重度新生儿缺氧血性脑病(HIE)的治疗效果。方法:用那络酮多巴酚丁胺联合治疗重度新生儿缺氧缺血性脑病20例,对照组20例。观察治疗前后血清超氧化物歧化酶(SOD)和丙二醛(MDA)的水平、脑CT的改变、NBNA评分及生后1~12月龄时精神运动发育商(DQ)以评价疗效。结果:观察组治疗后血清SOD和MDA的水平、脑CT,NBNA评分及DQ检测结果均明显优于对照组,各项指标经统计学处理两组差异有显著性意义(P<0.05,<0.01)。结论:应用那络酮多巴酚丁胺联合治疗重度新生儿缺氧缺血性脑病确有明显疗效。
Objective: To observe the therapeutic effect of naloxone combined with dobutamine on severe neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Twenty patients with severe neonatal hypoxic-ischemic encephalopathy were treated with naloxone, dobutamine and 20 patients in the control group. The levels of serum superoxide dismutase (SOD) and malondialdehyde (MDA), brain CT changes, NBNA score and psychomotor developmental quotient (DQ) of 1-12 months after birth were observed before and after treatment to evaluate the curative effect. Results: The levels of serum SOD and MDA in the observation group were significantly higher than those in the control group after brain CT, NBNA score and DQ test. The differences between the two groups were statistically significant (P <0.05, <0.01) ). CONCLUSIONS: The use of naloxone, dobutamine, has shown significant efficacy in the treatment of severe neonatal hypoxic-ischemic encephalopathy.