白血病抑制因子是一种多功能细胞因子。近来发现它不仅具有促进造血细胞和神经细胞生长、分化 ,促进周围神经再生等作用 ,还参与了炎症与哮喘的病理生理过程 ,它是调节神经系统和免疫系统之间相互作用的重要介质。本文综述了近年来白血病抑制因子在这一领域研究的新进展 ,旨在为探讨哮喘的发病机制和临床治疗提供理论依据。 Leukemia inhibitory factor is a multifunctional cytokine. Recently, it has been found not only to promote the growth and differentiation of hematopoietic cells and nerve cells, promote peripheral nerve regeneration, but also to participate in the pathophysiology of inflammation and asthma. It is an important mediator of the interaction between the nervous system and the immune system. This review summarizes recent advances in the research of leukemia inhibitory factor in this field and aims to provide a theoretical basis for exploring the pathogenesis and clinical treatment of asthma.