目的 :探讨癌基因与抑癌基因的表达与肺癌发生、发展的关系。方法 :对 6 1例肺肿瘤标本 ,用免疫组化方法同时检测癌基因Bcl 2、抑癌基因视网膜母细胞瘤 (Rb)、p53、p16。结果 :Rb与p16表达、p53与Bcl 2表达呈负相关 (P <0 .0 5) ,Rb与p53表达、p16与Bcl 2表达呈正相关 (P <0 .0 5)。结论 :肺癌的发生与发展是癌基因激活、抑癌基因失活及细胞凋亡调控基因异常等多基因损害的积累过程和协同作用使各细胞增殖调控途径失控 ,最终导致肺癌发生并使肺癌发展 Objective: To investigate the relationship between the expression of oncogenes and tumor suppressor genes and the occurrence and development of lung cancer. Methods : Sixty-one cases of lung tumors were examined by immunohistochemistry for simultaneous detection of oncogene Bcl 2 and tumor suppressor gene retinoblastoma (Rb), p53, and p16. Results: The expression of Rb and p16 was negatively correlated with the expression of p53 and Bcl 2 (P < 0.05). The expression of Rb and p53 was positively correlated with the expression of p16 and Bcl 2 (P <0. 05). Conclusion : The occurrence and development of lung cancer is the accumulation process and synergistic effects of oncogene activation, tumor suppressor gene inactivation and apoptosis control gene anomaly and other multi-gene damage, which leads to out-of-control of cell proliferation control pathways, eventually leading to lung cancer and lung cancer development.