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抗坏血酸(下称VitC)用作防治坏血病,促进创伤及骨折愈合。近年还用于急性型克山病,急慢性感染,防治感冒,降低胆固醇及治疗肝胆疾病等。随着VitC的广泛应用,临床上本品与某些药物合并使用也颇为常见。一、与磺胺药物的相互作用 Vitc与磺胺类药物配伍同用,由于Vitc结构中有烯醇羟基,具较醋酸高的酸性[1],其部分原型物由肾脏排泄时,无疑将会降低尿液pH值,使尿液酸化,此时,磺胺药及其乙酰化物在酸性环境下解离度变小,易析出结晶,损害肾脏,若VitC服用量较大,还可能产生尿酸盐和胱氨酸盐的沉积,出现尿酸结石,使磺胺药物的肾毒性增加,导致更
Ascorbic acid (hereinafter referred to as VitC) is used to prevent scurvy and promote wounds and fracture healing. In recent years, it is also used for acute Keshan disease, acute and chronic infections, prevention and treatment of colds, lowering of cholesterol and treatment of hepatobiliary diseases. With the wide application of VitC, the clinical use of this product in combination with some drugs is quite common. First, the interaction with sulfa drugs Vitc and sulfa drugs compatibility with the use of Vitc structure with enolic hydroxyl, with acetic acid high acidity [1], some of its prototype excretion by the kidneys, will undoubtedly reduce the urine Liquid pH value, so that urine acidification, this time, sulfa drugs and acetylation in acid environment smaller dissociation, easy precipitation crystallization, damage to the kidneys, if VitC taking larger, but also may produce urate and cyst The deposition of leucovorin, uric acid stones appear to increase the nephrotoxicity of sulfa drugs, resulting in more