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目的探讨单纯性肥胖症患儿血浆纤维蛋白原(Fg)水平及单体聚合功能改变。方法2004年9月至2006年12月在华北煤炭医学院附属医院检测106例单纯性肥胖症患儿和106名健康儿童的血浆Fg水平及单体聚合功能的变化,并进行两组比较。结果不同程度肥胖组患儿的血浆Fg浓度,纤维蛋白单体的聚合速度,最大光密度值,纤维蛋白单体的聚合速度与最大光密度值的比值,均明显高于对照组且差异有显著性(P<0.01);轻、中、重不同程度肥胖患儿的血浆Fg浓度,纤维蛋白单体的聚合速度,最大光密度值,纤维蛋白单体的聚合速度与最大光密度值的比值逐渐增高但差异无显著性(P>0.05)。结论儿童不同程度单纯性肥胖症都能够引起血浆Fg及单体聚合功能的异常,成为心、脑血管疾病发生的高危因素。
Objective To investigate the changes of plasma fibrinogen (Fg) and monomer polymerization in children with simple obesity. Methods From September 2004 to December 2006, 106 patients with simple obesity and 106 healthy children in the North China Coal Medical College Affiliated Hospital were tested for plasma Fg levels and monomer aggregation changes, and compared between the two groups. Results The plasma Fg concentration, the polymerization rate of fibrin monomer, the maximum optical density value, the polymerization rate of fibrin monomer and the maximum optical density value in obese children with different degrees of obesity were significantly higher than those of the control group with significant differences (P <0.01). The plasma Fg concentration, the polymerization rate of fibrin monomer, the maximum optical density, the polymerization rate of fibrin monomer and the ratio of maximum optical density gradually increased in children with mild, moderate and severe obesity But the difference was not significant (P> 0.05). Conclusion Children with different degrees of simple obesity can cause plasma Fg and monomeric aggregation abnormalities, a risk factor for the occurrence of cardiovascular and cerebrovascular diseases.