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目的:探讨亚急性联合变性(ＳＣＤ)的临床特点及电生理和核磁共振成像的诊断价值。方法:对１４例ＳＣＤ患者的临床资料进行回顾性分析。结果;发现所有ＳＣＤ患者发病均由维生素Ｂ１２缺乏所引起的肢体感觉异常,深感觉减退,共济失调及痉挛性轻瘫是ＳＣＤ常见的症状和体征。该病早期易误诊,电生理检查有极高的敏感性,核磁共振成像可以确定脱髓鞘的部位。结论:血清维生素Ｂ１２浓度测定、电生理及核磁共振检查对诊断和治疗有重要作用。
Objective: To investigate the clinical features of subacute combined degeneration (SCD) and the diagnostic value of electrophysiology and magnetic resonance imaging. Methods: The clinical data of 14 patients with SCD were analyzed retrospectively. Results: All patients with SCD were found to be experiencing abnormal limb sensation caused by vitamin B12 deficiency, deep hypodermisia, ataxia and spastic paraplegia, which were common symptoms and signs of SCD. Early misdiagnosis of the disease, electrophysiological examination with high sensitivity, magnetic resonance imaging can determine the demyelinating sites. Conclusion: Determination of serum vitamin B12 concentration, electrophysiological and MRI examination of the diagnosis and treatment have an important role.