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单纯疱疹病毒(herpes simplex virus,HSV)是一种嗜神经性双链 DNA 包膜病毒。HSV 有两个血清型,即1型(HSV-1)和2型(HSV-2),目前公认 HSV是病毒性脑炎的最常见病因,约占全部脑炎的10%～20%。随着对单纯疱疹病毒性脑炎发病机制研究的深入,发现 CD 40分子在多种病毒性脑炎中起重要作用并能影响小胶质细胞激活和小胶质细胞分泌细胞因子。本文拟就近年关于 CD 40分子-CD40L 分子(以下略去分子二字)在单纯疱疹病毒性脑炎(HSE)中作用的研究进展作一综述。1 CD 40-CD 40L 的生物学特性及其功能意义1.1 CD 40及 CD 40L 的结构与分布 CD 40是分子量为48 ku 的Ⅰ型跨膜糖蛋白,由227个氨基酸残
Herpes simplex virus (HSV) is a neurotropic dsDNA envelope virus. HSV has two serotypes, HSV-1 and HSV-2. HSV is currently recognized as the most common cause of viral encephalitis, accounting for 10% -20% of all encephalitis. With the further study on the pathogenesis of herpes simplex virus encephalitis, CD40 molecule was found to play an important role in a variety of viral encephalitis and could affect the activation of microglia and the secretion of cytokines by microglia. This article reviews the recent progress in the study of the role of CD40 molecule-CD40L (hereinafter abbreviated as molecular abbreviation) in herpes simplex virus encephalitis (HSE). 1 The biological characteristics of CD 40-CD 40L and its functional significance 1.1 The structure and distribution of CD 40 and CD 40L CD 40 is a type I transmembrane glycoprotein with a molecular weight of 48 ku, consisting of 227 amino acid residues