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自从1964年Prichard首先报道萘心定(pronthalol)的降压作用以来,β-肾上腺素能受体阻滞药物(β-阻滞剂)在高血压治疗中的应用已日益增多。对大多数无心力衰竭和支气管哮喘的高血压患者,β-阻滞剂是优先选择的药物。在比较严重的高血压病例,可与利尿剂合用,必要时则与血管扩张剂如肼苯哒嗪或哌唑嗪(prazosin)合用。也可与肾上腺素能神经元阻滞剂如苯胍(bethanidine)、胍喹啶(debrisoquine)和胍乙啶合用。
The use of β-adrenergic receptor blockers (β-blockers) in the treatment of hypertension has been increasing since Prichard first reported the antihypertensive effect of pronthalol in 1964. Β-blockers are the preferred drug for most hypertensive patients without heart failure and bronchial asthma. In more severe cases of hypertension, can be combined with diuretics, if necessary, and vasodilators such as hydralazine or prazosin (prazosin) combined. It can also be used with adrenergic neuron blockers such as bethanidine, debrisoquine and guanethidine.