丙型肝炎病毒(HCV)是对全球公众健康影响较为严重的一种病原,目前尚缺乏有效疫苗及针对性强的药物对其进行防控,究其原因是缺少有效的动物模型,使其致病机理研究较为薄弱。因此,建立一种有效的HCV感染动物模型是HCV研究工作中的重要环节。本文简要介绍了迄今为止国内外已建立的HCV感染动物模型的特点及其应用前景。 Hepatitis C virus (HCV) is a serious cause of global public health. Currently, there is a lack of effective vaccines and targeted drugs to prevent it. The reason for this is the lack of an effective animal model, The mechanism of disease is relatively weak. Therefore, establishing an effective animal model of HCV infection is an important part of HCV research. This article briefly introduced the characteristics of the established animal models of HCV infection both at home and abroad and its application prospects.