肺动脉高压是一组以肺动脉压力、肺血管阻力进行性增高,最终导致右心衰竭为特征的临床综合征。研究认为,在遗传因素的背景下,以缺氧、炎症、异常血流剪切力等因素作为诱因,通过血管内皮细胞、平滑肌细胞、血小板等细胞参与,体内异常细胞因子产生,相关分子信号途径传导障碍,导致肺动脉细胞增殖、凋亡功能紊乱,进而造成肺血管异常收缩、微血栓形成、肺小动脉重构,最终形成肺动脉高压。由于肺动脉高压是多种慢性心肺疾病常见而又严重的并发症,因 Pulmonary hypertension is a group of clinical syndromes characterized by pulmonary artery pressure and pulmonary vascular resistance that eventually lead to right heart failure. In the context of genetic factors, hypoxia, inflammation, abnormal shear flow and other factors were taken as the inducing factors. Through studies on the involvement of vascular endothelial cells, smooth muscle cells, platelets and other cells, abnormal cytokine production in vivo and related molecular signaling pathways Conduction disorder, leading to pulmonary artery cell proliferation, apoptosis dysfunction, resulting in abnormal pulmonary vascular contraction, micro-thrombosis, pulmonary arteriolar remodeling, and ultimately the formation of pulmonary hypertension. Because pulmonary hypertension is a common and serious complication of many chronic heart and lung diseases, due to