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采用免疫组化SP法检测了30例胃癌及相应切缘正常胃粘膜的Rb蛋白表达，以探讨Rb蛋白表达在胃癌发生中的作用及与临床生物学行为的关系。结果表明，胃癌中Rb蛋白表达率为66．67％，而正常胃粘膜中Rb蛋白100％表达，二者间Rb蛋白表达有明显统计学差异（P＜0．05）。因此Rb蛋白表达异常参与部分胃癌的发生。但Rb蛋白表达与组织学类型及淋巴结转移无关（P＞0．05）。
The immunohistochemical SP method was used to detect the expression of Rb protein in 30 cases of gastric cancer and corresponding margin normal gastric mucosa to explore the role of Rb protein expression in gastric carcinogenesis and its relationship with clinical biological behavior. The results showed that the expression rate of Rb protein in gastric cancer was 66.67%, while Rb protein in normal gastric mucosa was 100%. The expression of Rb protein was significantly different between them (P<0.05). Therefore, abnormal expression of Rb protein participates in the occurrence of part of gastric cancer. However, Rb protein expression was not associated with histological type and lymph node metastasis (P>0.05).