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目的探讨白细胞介素16基因(IL-16)rs4778889、rs11556218和rs4072111多态性与卵巢癌易感性的关系。方法收集285例健康对照和198例卵巢癌患者外周静脉血,采用聚合酶链反应-限制性片段长度多态性方法分析IL-16基因多态性与卵巢癌的相关性。结果 rs11556218TG基因型在卵巢癌中的频率为50.5%,明显高于其在对照组中的频率38.9%(χ2=6.65,校正OR=1.70,95%CI:1.16-2.48,P=0.006);rs11556218TG/GG基因型在卵巢癌中的频率为54.5%,明显高于其在对照组中的频率42.8%(χ2=6.45,校正OR=1.66,95%CI:1.15-2.40,P=0.007)。rs4778889和rs4072111基因型频率在卵巢癌和对照组中的分布差异无统计学意义(P>0.05)。结论 IL-16基因rs11556218多态性与卵巢癌的易感性有关。
Objective To investigate the association of interleukin 16 gene (IL-16) rs4778889, rs11556218 and rs4072111 polymorphisms with susceptibility to ovarian cancer. Methods Peripheral venous blood was collected from 285 healthy controls and 198 ovarian cancer patients. The association between IL-16 gene polymorphisms and ovarian cancer was analyzed by polymerase chain reaction-restriction fragment length polymorphism. Results The frequency of rs11556218TG genotype was 50.5% in ovarian cancer, which was significantly higher than that in control group (χ2 = 6.65, adjusted OR = 1.70, 95% CI: 1.16-2.48, P = 0.006); rs11556218TG / GG genotype was 54.5% in ovarian cancer, significantly higher than its frequency 42.8% in controls (χ2 = 6.45, adjusted OR = 1.66, 95% CI: 1.15-2.40, P = 0.007). There was no significant difference in the frequencies of rs4778889 and rs4072111 genotypes between ovarian cancer and control (P> 0.05). Conclusion IL-16 gene rs11556218 polymorphism is associated with the susceptibility to ovarian cancer.