目的探讨癌基因ｃｍｙｃ和ｐ５３在大肠腺瘤和大肠癌中的表达情况，及与临床病理特征的关系．方法采用免疫组化ＡＢＣ法，检测３９例大肠癌和３７例大肠腺瘤的ｃｍｙｃ表达，及６３例大肠癌和４０例大肠腺瘤的ｐ５３表达情况．结果大肠腺瘤３７例的ｃｍｙｃ阳性表达为６２２％（２３／３７），大肠癌３９例的ｃｍｙｃ阳性表达为８２１％（３２／３９）．而ｐ５３在大肠腺瘤和大肠癌的阳性表达则为４５０％（１８／４０）和８４１％（５３／６３）．ｃｍｙｃ和ｐ５３在大肠腺瘤和大肠癌中的表达均有显著的统计学意义（Ｐ＜００１）．但两个癌基因的表达均不相关于临床病理特征．结论ｃｍｙｃ与ｐ５３的异常表达大肠癌的演变过程中均有增加，而且两者起协作作用 Objective To investigate the expression of oncogene cmyc and p53 in colorectal adenoma and colorectal cancer, and their relationship with clinicopathological features. Methods Immunohistochemical ABC method was used to detect the expression of cmyc in 39 cases of colorectal cancer and 37 cases of colorectal adenoma, and the expression of p53 in 63 cases of colorectal cancer and 40 cases of colorectal adenoma. Results The expression of cmyc in 37 cases of colorectal adenoma was 622%(23/37). The positive expression of cmyc in colorectal carcinoma was 821%(32/39) in 39 cases. The positive expression of p53 in colorectal adenoma and colorectal cancer was 45.0% (18/40) and 84.1% (53/63). The expression of cmyc and p53 in colorectal adenoma and colorectal cancer were statistically significant (P<001). However, the expression of the two oncogenes was not related to the clinicopathological features. Conclusion The abnormal expression of cmyc and p53 has increased during the evolution of colorectal cancer, and the two work together.