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目的探讨漯河市妇女近3年HPV亚型感染特征及趋势。方法回顾性分析2014年1月-2016年8月我院妇产科门诊参加宫颈HPV分型检测的18 994例女性患者,分析感染情况及3年来感染趋势。结果 18 994例患者中,HPV感染率为22.5%,前5感染亚型分别为HPV16(5.3%),HPV52(3.5%),HPV58(2.9%),HPV53(2.6%),HPV39(2.1%);不同年龄组别中,15-25岁组(32.9%)和56-60岁组(29.7%)感染率较高;单纯高危亚型感染率为83.1%,高于单纯低危亚型感染(9.2%)及高+低危亚型感染(7.7%);一重感染率占74.6%,高于多重感染(25.4%)。2014、2015、2016年HPV总感染率分别为25.1%(1 531/6 093)、22.1%(1 794/8 128)、19.7%(944/4773),呈下降趋势。结论漯河地区妇产科门诊就诊患者中,15-25岁组和56-60岁组患者HPV感染率高,且以一重感染和高危感染为主,感染亚型以16、52、58较为常见;近三年漯河地区妇产科门诊HPV感染有下降趋势。
Objective To investigate the characteristics and trends of HPV subtype infection in women in Luohe city in recent 3 years. Methods A retrospective analysis of 18 994 female patients with gynecological and obstetric clinic attending HPV genotyping in our hospital from January 2014 to August 2016 was conducted to analyze the infection status and trend of infection in the past three years. Results Among 18 994 patients, the HPV infection rate was 22.5%. The first five subtypes were HPV16 (5.3%), HPV52 (3.5%), HPV58 . In different age groups, infection rate was higher in 15-25 years old group (32.9%) and 56-60 years old group (29.7%). The infection rate of high-risk subtype was 83.1%, which was higher than that of simple low-subtype infection 9.2%) and high + low risk subtypes (7.7%). The prevalence of severe infections was 74.6%, higher than that of multiple infections (25.4%). The total infection rates of HPV in 2014, 2015 and 2016 were 25.1% (1 531/6 093), 22.1% (1 794/8 128) and 19.7% (944/4773) respectively, showing a decreasing trend. Conclusion The prevalence of HPV infection in 15-25 years old and 56-60 years old patients in gynecology and obstetrics clinic in Luohe is high, and the infection rate is high. The infection subtypes are more common than 16,52,58. In the past three years, gynecological outpatient clinics in Luohe have a downward trend in HPV infection.