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环孢霉素A(CyclosporinA:CYA:CsA.下称CYA),是由11个氨基酸组成的环状多肽,分子量1203,不溶于水,易溶于油性溶媒和乙醇.可以多孢木霉菌和桂孢霉菌或某些镰刀菌株作产生菌获得。该药系瑞士Sandoz公司在70年代初期发现.美国FDA 1983年核准本品在美国注册出售,商品名Sandimmum.1984年我国CYA研究获得成功.CYA目前巳成为国外器官移植所用的首选药,对一些自身免疫病、血吸虫病、疟疾也有一定疗效,同时还是防治某些植物病害如苹果腐烂病系有希望的农药.目前CYA的研究已成为国际性的一个重要课题。
Cyclosporin A (CYA: CsA, hereinafter referred to as CYA) is a cyclic polypeptide consisting of 11 amino acids with a molecular weight of 1203, which is insoluble in water and soluble in oily vehicles and ethanol. Spore molds or some Fusarium strains for producing bacteria. The drug was discovered by the Swiss company Sandoz in the early 1970s and the FDA approved the product for sale in the United States in 1983 under the trade name Sandimmum CYA in 1984. CYA is currently the drug of choice for foreign organ transplantations Autoimmune diseases, schistosomiasis and malaria also have some curative effect, at the same time, they are also promising pesticides for controlling certain plant diseases such as apple rot disease.At present, the research of CYA has become an important issue in the world.