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组织学分级和病理学分期是检测膀胱癌患者治疗效果的一项极为重要的指标。然而,组织表现和肿瘤生物学行为间的关系仍未明瞭。业已发现,转铁蛋白受体表达与肿瘤细胞增殖密切相关。许多细胞均已发现转铁蛋白受体,因此认为该受体与细胞生长有关,所有增殖细胞均存在这一细胞表面糖蛋白。本文研究目的在于观察作为增殖活性指标的转铁蛋白受体与膀胱移行细胞癌分级和分期的相关性,以证实浸润性膀胱癌转铁蛋白受体表达阳性率高于表浅性膀胱癌的假说。收集68例经尿道切除膀胱肿瘤患者的组织标本,男59例,女9例,年龄31～94岁(平均66±12岁)。
Histological grading and pathological staging are extremely important indicators for the treatment of bladder cancer patients. However, the relationship between organizational performance and tumor biological behavior remains unclear. It has been found that transferrin receptor expression is closely related to tumor cell proliferation. Transferrin receptors have been found in many cells and it is thought that this receptor is involved in the growth of cells. This cell surface glycoprotein is present in all proliferating cells. The purpose of this study was to observe the correlation between the transferrin receptor, which is an index of proliferative activity, and the grading and staging of bladder transitional cell carcinoma, in order to confirm the hypothesis that the positive rate of transferrin receptor expression in invasive bladder cancer is higher than that of superficial bladder cancer. . Tissue specimens were collected from 68 patients who underwent urethral resection of bladder tumors. There were 59 males and 9 females, aged 31-94 years (mean, 66±12 years).