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本文采用锌试剂结合分光光度法，测定了咳特灵胶囊中马来酸氯苯那敏的含量。在ｐＨ４．５的条件下，马来酸氯苯那敏与锌试剂形成１：１的络合物，用氯仿提取，在５３５ｎｍ波长处测定吸收度。马来酸氯苯那敏浓度在３～１５μｇ／ｍｌ范围内符合比耳定律。方法回收率为９９．０％（ｎ＝９）ＲＳＤ＜１．５％。
In this paper, zinc reagent and spectrophotometry were used to determine the content of chlorpheniramine maleate in Keteling capsules. Chlorpheniramine maleate forms a 1: 1 complex with zinc reagent at pH 4.5 and is extracted with chloroform to determine absorbance at a wavelength of 535 nm. Beer’s law of chlorpheniramine concentration in the range of 3 ~ 15μg / ml. The method recovery was 99.0% (n = 9) RSD <1.5%.