报告血清铜、锌、镁及其相关酶活性在实验性甲亢和甲减时的变化。观察了甲亢对体重、心重的影响。结果表明:甲亢时血清铜、锌及铜/锌比值较对照组明显升高(P<0.001),镁含量明显降低(P<0.002),血清铜蓝蛋白(CP)氧化酶、血管紧张素转化酶(ACE)和硷性磷酸酶(ALP)活性明显升高(P<0.001)。锌与ACE 及ALP 活性呈显著正相关。铜与CP 氧化酶亦呈显著正相关。 Reported changes in serum copper, zinc, magnesium, and related enzyme activities during experimental hyperthyroidism and hypothyroidism. The effect of hyperthyroidism on body weight and heart weight was observed. The results showed that serum copper, zinc and copper/zinc ratios were significantly higher in hyperthyroidism than in controls (P<0.001), magnesium levels were significantly lower (P<0.002), serum ceruloplasmin (CP) oxidase, and angiotensin conversion The activities of enzymes (ACE) and alkaline phosphatase (ALP) were significantly increased (P<0.001). Zinc has a significant positive correlation with ACE and ALP activity. There was also a significant positive correlation between copper and CP oxidase.