近年来,从天然来源的黄酮类化合物出发,设计、合成细胞周期蛋白依赖性激酶(CDKs)抑制剂,是抗肿瘤药物研究的一个重要方向,许多具有抗肿瘤活性的类黄酮CDKs抑制剂已被报道,其中一些化合物已进入临床研究阶段。现对文献报道的类黄酮CDKs抑制剂的研究概况进行综述,为该类药物的进一步研发提供参考。 In recent years, from the natural sources of flavonoids, the design and synthesis of inhibitors of cyclin-dependent kinases (CDKs), is an important direction of anticancer drug research, many anti-tumor activity of flavonoid CDKs inhibitors have been Reported that some of these compounds have entered the clinical research phase. Now reported in the literature of flavonoids CDKs inhibitor overview, for the further development of these drugs provide a reference.