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目的高血压常并发靶器官损害。本研究的目的是观察正常高值血压患者肾功能的变化,以探讨正常高值血压患者是否存在与血压升高相关的靶器官损害,以指导其在高血压治疗和预防方面的意义。方法根据JNC-7诊断标准筛选病例并分为三组:正常血压组(NT组)为56例正常血压健康人,男性41例,女性15例,平均年龄(45.54±6.1)岁;正常高值血压组(PH组)为51例正常高值血压患者,男性37例,女性14例,平均年龄(46.04±6.2)岁;高血压组(EH组)为54例原发性高血压患者,男性40例,女性14例,平均年龄(49.06±5.3)岁;留取晨尿,抽取静脉血,离心后采用放免法和酶法测定尿β2-微球蛋白(β2-MG)、尿微量白蛋白(mAIb)及血尿素氮(BUN)、血肌酐(CR)。结果与NT组相比,PH组和EH组尿β2-微球蛋白(β2-MG)、尿微量白蛋白(mAIb)水平明显升高(P<0.05;P<0.0 1)。血尿素氮(BUN)、血肌酐(CR)在EH组明显升高,与NT组比较P<0.01;在PH组血尿素氮(BUN)轻度升高,与NT组比较无显著性差异;血肌酐(CR)明显升高,与NT组比较P<0.01。结论 PH组患者尿β2-MG、尿微量白蛋白(mAlb)、血肌酐(CR)出现了异常变化,提示正常高值血压患者可能存在与血压升高相关的肾损害。
The purpose of hypertension often complicated by target organ damage. The purpose of this study was to observe the changes of renal function in patients with normal high blood pressure and to explore the existence of target organ damage associated with elevated blood pressure in patients with normal high blood pressure to guide its significance in the treatment and prevention of hypertension. Methods According to the diagnostic criteria of JNC-7, the patients were divided into three groups: normotensive group (NT group), 56 normal healthy subjects, 41 males and 15 females, with an average age of 45.54 ± 6.1 years; The blood pressure group (PH group) consisted of 51 patients with normal high blood pressure, including 37 males and 14 females, with an average age of (46.04 ± 6.2) years. In the hypertension group (EH group), 54 patients with essential hypertension were male 40 cases, 14 females, average age (49.06 ± 5.3) years old; morning urine was taken, venous blood was drawn, centrifuged and radioimmunoassay was used to detect urinary β2-microglobulin (mAIb), blood urea nitrogen (BUN) and serum creatinine (CR). Results Compared with NT group, the levels of urinary β2-microglobulin (mAb) and urinary albumin (mAb) in PH group and EH group were significantly increased (P <0.05; P <0.01). Blood urea nitrogen (BUN) and serum creatinine (CR) in EH group were significantly higher than those in NT group (P <0.01). Blood urea nitrogen (BUN) slightly increased in PH group, but no significant difference compared with NT group Serum creatinine (CR) was significantly higher than that in NT group (P <0.01). Conclusion The abnormal changes of urinary β2-MG, mAlb, and serum creatinine (CR) in patients with PH indicate that there may be renal damage associated with elevated blood pressure in patients with normal high blood pressure.