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青蒿素是青蒿(Artemisia annua L.)中分离出来的一种新型的倍半萜内酯化合物,其化学结构完全不同于喹啉类药物,具有高效、速效和低毒的抗疟性能,对凶险型疟疾和抗氯喹株的患者疗效更为突出。青蒿虽然分布很广,但不同产地植株的青蒿素含量差异较大。青蒿素化学结构复杂,人工合成难度较大。通过组织培养方法阐明青蒿素形成途径及其与环境条件的关系对提高有效含量和指导人工合成都是很有意义的。本文报道诱导青蒿愈伤组织及分化再生成植株过程中青蒿素含量的变化。
Artemisinin is a new type of sesquiterpene lactone compound isolated from Artemisia annua L. Its chemical structure is completely different from that of quinoline drugs. It has high anti-malarial properties with high efficiency, quick response and low toxicity. More effective in treating patients with aggressive malaria and chloroquine resistant strains. Although the distribution of Artemisia annua is very broad, the content of artemisinin in different producing areas is quite different. Artemisinin complex chemical structure, artificial synthesis is more difficult. It is significant to elucidate the pathway of artemisinin formation and its relationship with environmental conditions through tissue culture methods to improve the effective content and guide the synthesis of artemisinin. This article reports the changes of artemisinin content in the process of inducing A. annua callus and regenerating into plants.