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目的探讨C-反应蛋白与高血压的关系以及与其他心血管病危险因素的交互作用对高血压的影响。方法在蒙古族高血压现况调查基础上,采用病例对照研究方法,选择年龄≥30岁的高血压患者767人,对照762例,进行有关危险因素分析和身体指标的测量,采集血标本并进行血脂、血糖、胰岛素和C-反应蛋白含量检测。使用SPSS 13.0软件进行统计分析。结果病例组C-反应蛋白含量为(2.10±0.83)mg/L,高于对照组的(1.80±0.77)mg/L,差异有统计学意义(P<0.01)。按照C-反应蛋白含量将研究对象等分为<1.40,1.40~1.83,1.84~2.53,≥2.54 mg/L 4组,以C-反应蛋白含量最低组作为参照,调整其他因素影响后,其他3组由低到高与高血压关联的OR值分别为1.144(95%CI=0.840~1.559),1.330(95%CI=0.970~1.824)和1.556(95%CI=1.116~2.172),存在高血压的患病危险随着C-反应蛋白升高而增高的趋势(χMH2=7.397,P=0.007)。调整其他因素的影响后,吸烟、胰岛素抵抗与C-反应蛋白高含量的联合作用对高血压有正相加交互作用,交互效应超额相对危险度分别为0.799(P<0.01)和0.651(P<0.05)。结论C-反应蛋白水平与高血压患病危险相关联;吸烟、胰岛素抵抗与C-反应蛋白高含量对高血压的患病危险有交互作用。
Objective To investigate the relationship between C-reactive protein and hypertension and its interaction with other cardiovascular risk factors on hypertension. Methods A case-control study was conducted on the basis of a survey of the prevalence of hypertension in Mongolian ethnicity. Seven hundred and sixteen hypertensive patients aged ≥30 years and 762 controls were selected for risk factor analysis and physical measurement. Blood samples were collected and processed Blood lipids, blood glucose, insulin and C-reactive protein levels were measured. SPSS 13.0 software for statistical analysis. Results The level of C-reactive protein in the patients was (2.10 ± 0.83) mg / L, which was significantly higher than that in the control group (1.80 ± 0.77) mg / L (P <0.01). According to the content of C-reactive protein, the subjects were equally divided into four groups of <1.40,1.40-1.83,1.84-2.53, ≥2.54 mg / L, with the lowest C-reactive protein content as the reference, after adjusting for other factors, The odds ratios (ORs) were 1.144 (95% CI = 0.840-1.559), 1.330 (95% CI = 0.970-1.824) and 1.556 (95% CI = 1.116-2.17 2) in the group from low to high, The prevalence tended to increase as C-reactive protein increased (χMH2 = 7.397, P = 0.007). After adjusting for other factors, the combined effects of smoking, insulin resistance and high C-reactive protein levels had positive interactions with hypertension, and the excess relative risk of interaction was 0.799 (P <0.01) and 0.651 (P < 0.05). Conclusions C-reactive protein level is associated with the risk of hypertension. Smoking, insulin resistance and high C-reactive protein levels have an interaction effect on the prevalence of hypertension.