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目的:阐明Ｐ型谷胱甘肽转硫酶(ＧＳＴＰ１)基因多态性与易患帕金森病之间的关系。方法:帕金森病组:１１３例;对照组:７７例,两组人员年龄与性别是基本匹配。利用聚合酶链反应．限制性片断长度多态性技术检测ＧＳＴＰ１基因多态性。结果:经二值多元Ｌｏｇｉｓｉｔｉｃ回归分析,帕金森病组ＧＳＴＰ１的等位基因Ａ和基因型Ａ/Ａ的频率均高于对照组,且罹患帕金森病的危险率比对照组增加２．１６倍。结论:本研究结果提示ＧＳＴＰ１的基因多态性可能与帕金森病的遗传易患有关。
Objective: To clarify the relationship between P-type glutathione S-transferase (GSTP1) gene polymorphism and predisposition to Parkinson’s disease. Methods: Parkinson’s disease group: 113 cases; control group: 77 cases. The age and sex of the two groups were basically matched. Using polymerase chain reaction. Detection of GSTP1 Gene Polymorphism by Restriction Fragment Length Polymorphism. Results: By binary multivariate logistic regression analysis, the frequencies of allele A and genotype A / A of GSTP1 in Parkinson disease group were higher than those in control group, and the risk of Parkinson’s disease was 2.16 times higher than that in control group . Conclusion: Our results suggest that GSTP1 gene polymorphism may be related to the genetic predisposition to Parkinson’s disease.