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慢性燃煤型砷中毒是我国特有的一种公共卫生问题,由于长期从燃烧煤污染的室内空气和食物等环境介质中摄入过量的砷所致。近年来,燃煤型砷中毒所导致的肺损害引起较多的关注,此类肺损害多以慢性肺纤维化为主要表现,但具体发病机制仍不清楚,同时缺乏特效药物治疗。本研究尝试使用汉防己甲素和乙酰半胱氨酸对此类肺损害进行治疗,观察该疗法对患者肺功能和血清蛋白标志物的影响。1对象与方法1.1研究对象36例患者均来自开封市及其周边受
Chronic coal-burning arsenic poisoning is a peculiar public health problem in our country. It is caused by long-term intake of excess arsenic from environmental media such as indoor air and foodstuffs that burn coal. In recent years, the lung damage caused by coal-burning arsenic poisoning has attracted more attention. Such lung damage mostly takes chronic pulmonary fibrosis as the main manifestation, but the specific pathogenesis is still unclear, and there is no specific drug treatment. This study attempts to use tetrandrine and acetylcysteine for the treatment of such lung damage, observe the effect of this therapy on lung function and serum protein markers in patients. 1 Subjects and Methods 1.1 Study Subject 36 patients were from Kaifeng City and its peripheral subject