近年研究发现,细菌胞嘧啶鸟嘌呤二核苷酸(CpGDNA)和合成的含CpG序列的寡脱氧核苷酸(CpG ODN)具有强烈的非特异性的免疫刺激作用,其共同特征为都含有一些具有免疫学活性的短核苷酸序列。美国依阿华大学医学院Krieg等将此类特定结构称为CpG基元,另外有人称其为CpG免疫刺激序列(ISS)。多年来,细菌DNA(bDNA)被认为是没有免疫作用的,但在漫长的进化过程中,脊椎动物的免 Recent studies have found that bacterial cytosine guanine dinucleotide (CpGDNA) and synthetic CpG ODN contain a strong nonspecific immunostimulatory effect, all of which have the common feature of containing a Immunologically active short nucleotide sequence. The United States Iowa University School of Medicine Krieg and other such structures will be called CpG motifs, others were called CpG immune stimulation sequence (ISS). For many years, bacterial DNA (bDNA) was thought to have no immunological effect, but vertebrates were immune to long evolutionary processes