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为科学制订国产BRDⅡ株风疹疫苗初次免疫程序，作者对268名6～18月龄组儿童初免风疹疫苗前后风疹血凝抑制（HI）抗体水平进行了血清学研究。结果表明：在6、7、8、9、12和18月龄组儿童中，风疹疫苗免前HI抗体的阴性率分别为100．00％、95．56％、93．02％、96．36％、97．96％和93．94％，几何平均滴度（GMT）分别为0．00、1．17、1．21、1．12、1．07和1．13．各级之间的差异无显著性意义（P＞0．05）；初免风疹疫苗1个月后，其免疫成功率分别为97.67％、95．56％、97．67％、98.18％、97．96％和96．67％，GMT分别为110．71、197．02、155．32、177．63、192．92和142．17，各组之间的差异亦无显著性意义（P＞0．05），且免前低滴度HI抗体对免疫应答结果无明显影响。另外，蓬莱、海阳两市儿童母亲风疹HI抗体的阳性率分别为85．59％和94.67％，其差异具有显著性意义（x2＝5．40，P＜0．05）。鉴于上述结果及我国现行的儿童计划免疫程序，作者建议国产风疹疫苗的起始免疫月龄定为儿童出生后8月龄接种为宜。
In order to scientifically establish the primary immunization program of domestic BRDⅡ strain of rubella vaccine, the serological study was conducted on the levels of rubella-haemagglutinating inhibition (HI) antibody in 268 children aged 6 to 18 months before and after initial rubella vaccine. The results showed that among the 6, 7, 8, 9, 12 and 18 month-old children, the negative rates of pre-immune HI antibody of rubella vaccine were 100.00%, 95.56%, 93.02% and 96.36 %, 97.96% and 93.94%, respectively. The geometric mean titers (GMT) were 0.00, 1.17, 1.21, 1.12, 1.07 and 1.13, respectively. There was no significant difference among all levels (P> 0.05). The immunization success rates of primary immunization rubella vaccine after 1 month were 97.67%, 95.56%, 97.67%, 98.18%, 97 .96% and 96.67%, respectively. The GMTs were 110.71, 197.02, 155.32, 177.63, 192.92 and 142.17, respectively. There was no significant difference between groups (P> 0.05), and no pre-low titer HI antibody had no significant effect on the immune response. In addition, the positive rates of Rubella HI antibody in children mothers in Penglai and Haiyang were 85.59% and 94.67%, respectively, with significant difference (x2 = 5.40, P <0.05). In view of the above results and the current program of immunization for children in our country, the author suggests that the initial immunization of domestic rubella vaccine should be given at the age of 8 months after birth.