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目的 探讨急性白血病细胞P170蛋白表达与化疗疗效和预后的关系。方法 应用免疫细胞化学APAAP法检测急性白血病P170表达。结果 60例初治急性白血病 (AL )的P170阳性表达率为 2 3 .3 %,在AML各亚型中 ,以急性早幼粒细胞白血病 (APL )的P170阳性表达率最低 ,可评价化疗效果者 48例 ,P170阴性组总缓解率为 82 .9%,P170阳性组总缓解率为 3 0 .8%,2组有非常显著性差异 (P <0 .0 1)。结论 P170阳性表达与AL的化疗疗效和预后密切相关 ,是不利的预后因素之一。
Objective To investigate the relationship between the expression of P170 in acute leukemia and the efficacy and prognosis of chemotherapy. Methods The APAAP method was used to detect the expression of P170 in acute leukemia. Results The positive expression rate of P170 in 60 cases of newly diagnosed acute leukemia (AL) was 23.3%. Among the AML subtypes, the positive rate of P170 in APL was the lowest, and the effect of chemotherapy was evaluated In 48 cases, the total remission rate of P170 negative group was 82.9%, and the total remission rate of P170 positive group was 30.8%. There was a significant difference between the two groups (P <0.01). Conclusion The positive expression of P170 is closely related to the chemotherapy efficacy and prognosis of AL, which is one of the unfavorable prognostic factors.