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目的分析氢氯噻嗪联合氨氯地平对老年高血压患者血压及肾功能的影响。方法选取在我院进行治疗的老年高血压患者86例,所有患者均服用降压药物进行洗脱治疗。按抽签顺序分为2组,各43例。对照组实施氢氯噻嗪治疗,研究组在对照组基础上加用氨氯地平治疗,对比2组患者治疗前后血压及肾功能指标变化情况。结果治疗后,研究组24 h平均血压、24 h血压变异率明显降低,差异有统计学意义(P<0.05);研究组尿白蛋白/血肌酐及24h尿微量白蛋白指标较对照组明显降低,内生肌酐清除率指标明显提高,差异有统计学意义(P<0.05)。结论对老年高血压患者实施氢氯噻嗪联合氨氯地平治疗,可有效降低血压水平,改善患者肾功能。
Objective To analyze the effect of hydrochlorothiazide combined with amlodipine on blood pressure and renal function in elderly patients with hypertension. Methods Totally 86 elderly hypertensive patients were treated in our hospital. All patients were given antihypertensive drugs for elution. According to the order of lottery divided into 2 groups, each 43 cases. The control group was treated with hydrochlorothiazide. The study group was treated with amlodipine on the basis of the control group. The changes of blood pressure and renal function before and after treatment were compared between the two groups. Results After treatment, the average blood pressure at 24 h and the variation rate of blood pressure at 24 h were significantly lower in the study group (P <0.05). Urinary albumin / serum creatinine and 24h urinary albumin in study group were significantly lower than those in control group , Endogenous creatinine clearance index was significantly improved, the difference was statistically significant (P <0.05). Conclusions Hydrochlorothiazide combined with amlodipine can effectively lower blood pressure and improve renal function in elderly hypertensive patients.