近年来,志贺氏菌属对氨苄青霉素和复方新诺明的耐药性逐渐增加。据报道,目前有90％以上的Ⅰ型痢疾志贺氏菌对这两种抗生素耐药。由于新喹诺酮制剂在体外试验中对志贺氏菌属(包括对萘啶酸耐药株)有较高的活性,因此作者用丙氟哌酸和氨苄青霉素对121例患有严重细菌性痢疾的男性成人住院者进行了随机双盲对照试验。 In recent years, Shigella resistance to ampicillin and cotrimoxazole gradually increased. It is reported that at present, more than 90% of Shigella dysenteriae type I are resistant to the two antibiotics. Because of the high activity of neoquinolone formulations in vitro for Shigella, including nalidixic-resistant strains, the authors used prophylactic and ampicillin to treat 121 patients with severe bacillary dysentery Male adult residents were randomized double-blind controlled trials.